Trinity College Dublin (TCD) School of Pharmacy

Trinity College Dublin (TCD) School of Pharmacy

Research in Pharmaceutics and Pharmaceutical Technology in the School of Pharmacy and Pharmaceutical Sciences, Trinity College Dublin is aimed at increasing our understanding of the physiochemical properties of active and excipient materials used in a variety of different dosage forms, and using that knowledge to improve product design in terms of in vitro and subsequently in vivo performance. Research areas of particular interest are advanced drug delivery (oral and pulmonary) and pharmaceutical nanoscience.

A particular focus of the group is in physicochemical characterisation and stability of solid state forms of active pharmaceutical ingredients.
Research involves salts/co-crystals screening, processing and co-processing of drugs and excipients by spray drying (including process factorial design), freeze drying and milling for oral and pulmonary delivery.
Particle engineering and micromeritic characterisation of novel drug forms comprises morphology characterisation by scanning electron microscopy, particle size distribution analysis by laser diffraction or dynamic light scattering, specific surface area analysis by BET as well as density and powder rheology measurement.

Chemical analysis is undertaken by techniques such as high performance liquid chromatography, gas chromatography, mass spectrometry and Fourier transform infrared analysis.
Studies on the physical nature of the solid state involve characterisation of amorphous and crystalline forms by powder and single crystal X-ray diffraction, true density and thermal analyses: differential scanning calorimetry including modulated temperature DSC and fast heating rate DSC as well as thermogravimetric analysis. Dynamic vapour sorption analyser is used to characterise hygroscopicity, solvation and amorphous phases while inverse gas chromatography is used to assess surface energy.
The laboratory is equipped with tablet press, capsule filler and a range of pharmacopoeial equipment to test tablets and capsules, for example UV flow-through and conventional dissolution test stations, hardness, friability and texture analysers. Pulmonary dosage forms may be produced as pressurised or dry powder inhalers and characterised using a next generation impactor, Andersen cascade impactor or twin-impinger. 
As part of the Solid State Pharmaceutical Cluster Strand III: the API/Formulation Interface, we collaborate with the School of Pharmacy, University College Cork to provide professional training and workshops on preformulation and formulation.

Trinity College Dublin (TCD) School of Pharmacy
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